The Coordinates of Truth

摘要

The scientific method has driven conceptual inquiry for centuries and still forms the basis of scientific investigation. Yet, the hypothesis-based research paradigm itself has received scant attention recently. Here, I propose an alternative model for this paradigm, based on decision, information, and game theory. Analysis of biomedical research efforts with this model may provide a framework for predicting their likely contributions to knowledge, assessing their impact on human health, and managing research priorities.