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Studies Point to Possible Contamination in XMRV Findings

机译:研究指出XMRV结果可能受到污染

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The stormy debate over a potential cause of chronic fatigue syndrome (CFS) is nearing hurricane force. Last month, it prompted headlines suggesting that researchers have reached a dead end, scores of blog posts from disappointed patients, and accusations that scientists had gone beyond their data. The 14-month-old row intensified when four papers appeared in Retrovirology suggesting that reports linking the virus XMRV to CFS were based on false positives. The debate began in 2009 with a report in Science that XMRV, a retrovirus recently reported to have been found in prostate tumors, had been detected in 67% of a set of CFS patients but in only 4% of controls {Science, 9 October 2009, p. 215). Since then, one other group has found XMRV-like viruses in CFS patients' blood. But several teams have failed to detect the virus in CFS or cancer patients or in healthy people. Researchers have struggled to explain the discrepancies {Science, 17 September 2010, p. 1454).
机译:关于慢性疲劳综合症(CFS)潜在原因的激烈争论正在逼近飓风。上个月,它引起了头条新闻,表明研究人员已经走到了尽头,数十名来自失望患者的博客文章,以及指责科学家超出了他们的数据。当在Retrovirology中出现四篇论文时,这个14个月大的行激化了,这表明将XMRV病毒与CFS关联的报道是基于假阳性。辩论始于2009年的《科学》杂志报道,XMRV是一种最近报道的在前列腺肿瘤中发现的逆转录病毒,在67%的CFS患者中检出,但仅在4%的对照中检出{Science,2009年10月9日,第215)。从那以后,另一小组在CFS患者的血液中发现了类似XMRV的病毒。但是,有几个团队未能在CFS,癌症患者或健康人群中检测到该病毒。研究人员一直在努力解释差异{Science,17 September 2010,p。 1454)。

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  • 来源
    《Science》 |2011年第6013期|p.17|共1页
  • 作者

    JOCELYN KAISER;

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  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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