The Unusual Case of Porcupine

摘要

Earlier this year, with little fanfare, one of the first small molecules targeting Wnt-mediated cellular signaling, called LGK974, entered a phase I clinical trial. Cell signaling that is controlled by secreted Wnt proteins is pivotal in animal development and tissue homeostasis, and has become a high-priority anticancer drug target given its essential role in colorectal cancer and its contribution to a broad range of other cancer types (1, 2).