Multiple sclerosis (MS) is a severely debilitating degenerative disease of the central nervous system. Resident macrophages of the brain, called microglia, are thought to be an important driver of disease. Factors that promote the conversion of proinflammatory, or so-called "Ml" microglia, which are thought to be the type of microglia that contribute to disease, into less dangerous, immunoregulatory "M2"-type microglia, are of therapeutic interest.
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