New gene editors fix common typos

摘要

New gene-editing tools can correct typos that account for about half of disease-causing genetic spelling errors. Scientists have revamped the CRISPR/ Cas9 gene editor so it converts the DNA base adenine to guanine, biological chemist David Liu and colleagues report online October 25 in Nature. In a separate study, published online October 25 in Science, a research team led by CRISPR pioneer Feng Zhang reengineered a gene editor called CRISPR/Casl3 to correct the same typos in RNA instead of DNA.