A NOVEL SYNTHESIS OF SOME 4-HYDROXY COUMARIN DERIVATIVES AND THEIR BIOLOGICAL ASSAYS

摘要

4-hydroxy-3- [1, 2, 3,4-tetrahydro-3-[4-(4 trifluoromethyl beuzyloxy) phenylj-1-naphthyl] coumarin have been synthesised from readily available materials. These have been seperated into cis & trans-forms. Their biological activities have been evaluated for the NO generation and anti excitotoxicity in vitro. Trans-isomer has been found to be potent suppressor of NO generation with the concentration of 10μ M invitro.