Therapeutic Potential of Phosphatidylinositol 3' Kinase (PI3K) Inhibitors in Cervical Cancer

摘要

Cervical cancer is a major public health issue and the second most prevalent cancer in Indian women. The phosphatidylinositol 3' kinase (PI3K)/ protein kinase B (Akt) signalling pathway plays an important role in development and progression of cervical cancers. Thus, the PI3K/AM pathway could be a potential therapeutic target for cancer treatment. Inhibition of PI3K/Akt mediated signalling by using specific synthetic inhibitors or natural phytochemicals with anti-tumorigenic potential could have important therapeutic applications for treatment of malignant cervical cancers.