Improved process for the preparation of pipamperone dihydrochlorlde

摘要

Herein is disclosed an improved process for the preparation of pipamperone dihydrochloride, eompound (1) of Scheme 1, the chemical name is 1-[4-(4-fhuorophcnyl)-4-oxobutyl]-4-piperidin-1-yipiperidine-4-carboxamide dihydrochloride, which is a typical antipsychotic of the butyrophenone family used in the treatment of schizophrenia.