Effects of a Single and Low Dose of Mifepristone on Integrin Expression in Human Endometrium During the Peri-implantation Period

摘要

Objective In order to gain further information about the mechanism of emergency contraception, during the peri-implantation period the effect of single and low dose of Mifepristone on the expression of integrin level in endometrium of healthy women were observed Materials & Methods Eleven healthy women, proven fertility, were randomly divided into two groups: group LH - 2 (n = 5) and LH + 2 (n = 6). During the control and treatment cycle, placebo or 10 mg Mifepristone were given orally to group LH - 2 on cycle day LH - 2 or to group LH + 2 on cycle day LH + 2, respectively. One endome-trial tissue specimen was obtained in both the control and the treatment cycle on cycle day LH + 7. In this study, the endometrial specimens were assessed by immunohis-tochemistry analysis to measure the change of integrin α_1, α_4 and β_3 subunits expression on the endometrium after using Mifepristone. Results Mifepristone increased the expression of α_1 and α_4 subunit in glandular epithelium only in group LH - 2. The expression of β_ integrin subunit remain the same in our experiments. Conclusion Treatment with Mifepristone interferes with integrin distribution during the implantation period, which may imply that the contraceptive effect of Mifepristone is primarily due to impaired endometrial receptivity.