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Hormonal activity of AIMP1/p43 for glucose homeostasis

机译:AIMP1 / p43对葡萄糖稳态的激素活性

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摘要

AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic α cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.
机译:AIMP1 / p43被称为在控制血管生成,炎症和伤口愈合中起作用的细胞因子。在这里,我们报告其在胰腺α细胞和胰高血糖素样激素活性中的富集。葡萄糖饥饿时,胰腺会分泌AIMP1。在禁食条件下,与野生型小鼠相比,AIMP1的外源输注增加了血浆中葡萄糖,胰高血糖素和脂肪酸的水平,而AIMP1缺陷型小鼠的血浆葡萄糖水平降低了。因此,AIMP1在葡萄糖稳态中起胰高血糖素样作用。

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