• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness
【24h】

Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness

机译：丙泊酚引起的意识丧失发作时神经网络的快速破碎

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

General anesthesia involves rapidly inducing a reversible coma by administering a large dose of a fast-acting drug, such as propofol. Previous research has demonstrated that propofol enhances inhibitory input to neurons throughout the spinal cord, brainstem, thalamus, and cortex (1). However, how these effects in single cells translate to larger-scale neural circuits and cause unconsciousness is not well understood. We recorded spiking activity from ensembles of single neurons and intracranial electrical activity during the induction of propofol general anesthesia in human subjects undergoing surgery.
机译：全身麻醉涉及通过施用大剂量的速效药物（如丙泊酚）来迅速诱发可逆性昏迷。先前的研究表明，丙泊酚可增强整个脊髓，脑干，丘脑和皮质神经元的抑制性输入（1）。然而，这些作用在单细胞中如何转化为更大范围的神经回路并引起意识丧失，目前尚不清楚。我们记录了在接受手术的人类受试者中异丙酚全麻诱导过程中单个神经元集合的尖峰活动和颅内电活动。

著录项

  • 来源
  • 作者

    Laura D. Lewis; Veronica S. Weiner; Eran A. Mukamel; Jacob A. Donoghue; Emad N. Eskandar; Joseph R. Madsen; William S. Anderson; Leigh R. Hochberg; Sydney S. Cash; Emery N. Brown; Patrick L. Purdon;

  • 作者单位

    Department of Brain and Cognitive Sciences Massachusetts Institute of Technology, Cambridge, MA 02139;

    Department of Brain and Cognitive Sciences Massachusetts Institute of Technology, Cambridge, MA 02139;

    Center for Brain Science, Harvard University, Cambridge, MA 02138,Xenter for Theoretical Biological Physics,University of California at San Diego, La Jolla, CA 92093;

    Departments of Neurology, and Harvard Medical School, Boston, MA 02115,Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology,Massachusetts Institute of Technology, Cambridge, MA 02139;

    Departments of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114,Departments of Surgery,Harvard Medical School, Boston, MA 02115;

    Departments of Surgery,Harvard Medical School, Boston, MA 02115,Department of Neurosurgery, Boston Children's Hospital, Boston, MA 02115;

    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287;

    Departments of Neurology, and Massachusetts General Hospital, Boston, MA 02114,Rehabilitation Research and Development Service, Department of Veterans Affairs, Providence, Rl 02908,institute for Brain Science, School of Engineering, Brown University, Providence, Rl 02912;

    Departments of Neurology, and Massachusetts General Hospital, Boston, MA 02114,Departments of Neurology, and Harvard Medical School, Boston, MA 02115;

    Department of Brain and Cognitive Sciences Massachusetts Institute of Technology, Cambridge, MA 02139,Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology,Massachusetts Institute of Technology, Cambridge, MA 02139,Departments of Anesthesia Harvard Medical School, Boston, MA 02115,Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139;

    Departments of Anesthesia, Critical Care and Pain Medicine,Massachusetts General Hospital, Boston, MA 02114,Departments of Anesthesia Harvard Medical School, Boston, MA 02115;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号