Target genes of Topoisomerase lip regulate neuronal survival and are defined by their chromatin state

摘要

Topoisomerases are enzymes crucial for solving topological constraints in DNA that result from DNA twisting during fundamental cellular events such as DNA replication (1). Members of the type II subfamily of topoisomerases create double-strand breaks in DNA and pass a region of duplex from the same or a different molecule through this double-stranded gap. Little is known about the cellular role of one member of this subfamily, Topoisomerase lip (Top2p). Here, we studied the supposed function of Top2p in neuronal development and found that it binds to gene regulatory regions and modulates the activity of genes that control neuronal differentiation and survival.