The CXC chemokine stromal cell-derived factor 1 is not responsible for CD8~+ T cell suppression of syncytia-inducing strains of HIV-1

摘要

Primary CD8+ T cells from HIV~+ asymptom- atics can suppress virus production from CD4~+ T cells acutely infected with either non-syncytia-inducing (NSI) or syncytia- inducing (SI) HIV-1 isolates. NSI strains of HIV-1 predomi- nantly use the CCR5 chemokine receptor as a fusion cofactor, whereas fusion of T cell line-adapted SI isolates is mediated by another chemokine receptor, CXCR4. The CCR5 ligands RAN- TES (regulated on activation, normal T cell expressed and secreted), macrophage inflammatory protein 1α (MIP-1α), and MIP-1β are HIV-1 suppressive factors secreted by CD8+ cells that inhibit NSI viruses.