Synthesis of 6H-pyrrolo[3 ′,4 ′ :2,3][1,4]diazepino[6,7,1-hi]indole-8,10(7H,9H)-diones using 3-bromo-4-(indol-l-yl)maleimide scaffold

摘要

Series of 3-arylalkyl- or 3-alkylamino-4-(indol-l-yl)maleimides and bis(indol-l-yl)maleimides were synthesised. The cyclization of the 3-substituted 4-(indol-l-yl)maleimides under the action of acids resulted in the formation of diazepine[l,4] derivatives with indoline and maleimide nuclei annelated. These compounds readily produced the corresponding indolomaleimidodiazepines[l,4] after dehydrogenation.