Synthesis and application of a new chiral monodentate spiro phosphoramidite ligand based on hexamethyl-1,1'-spirobiindane backbone in asymmetric hydroamination/arylation of alkenes

摘要

The design and synthesis of a new chiral monodentate Spiro phosphoramidite ligand based on a hexamethyt-1,1'-spirobiindane scaffold has been accomplished. The ligand could serve as an elegant chiral monodentate ligand in the Pd-catalyzed asymmetric hydroamination/arytation of alkenes leading to chiral imidazolidin-2-ones with good enantioselectivities.