Three-dimensional fluorescence optical tomography in small-animal imaging using simultaneous positron-emission-tomography priors

摘要

We propose three-dimensional fluorescence optical tomography imaging for small animals guided by simul-ntaneous priors from positron emission tomography (PET). Using a sparsity regularization, the target priornfrom PET images was incorporated into the reconstruction algorithm for optical imaging. The method andnalgorithms are validated with numerical simulations and a phantom experiment performed on a combinednoptical-PET scanner based on a conical mirror geometry. © 2009 Optical Society of America