Stochastic cancer models: application to analyses of solid cancer incidence in the cohort of A-bomb survivors

摘要

This paper gives a brief overview of multi-stage models of carcinogenesis, with an emphasis on the two-muta- tion clonal expansion model. It goes on the present an analysis of the incidence of solid cancers among A-bomb survivor, using incidence functions derived from the two-mutation clonal expansion model, and concludes with a discussion of the findings.