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YOUR HEART'S DESIRE

机译:您的心愿

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摘要

It's the biggest killer in the developed world. Even if you are spared, chances are that cardiovascular disease will claim a third of your friends and loved ones. Before they die, many will endure major surgery, years of dependence on drugs and the uncertainty of living with a terminal condition. The incentive to find a cure is huge. What if there's a simple treatment that could do away with open-heart surgery, perhaps even prevent heart attacks altogether? Sounds too good to be true? Well, there is a catch. Patients would be injected with proteins or the DNA that codes for them. But these "growth factors" are the same proteins that cancer cells pump out to trick the body into sprouting new capillaries to feed the tumour. Cancer researchers are understandably keen to turn off this angiogenesis. A few pioneers, though, realised that being able to grow blood vessels at will would be a formidable weapon against cardiovascular disease―even if it means injecting patients with bits of DNA from tumours.
机译:它是发达国家中最大的杀手。即使您幸免,心血管疾病也可能夺走您三分之一的朋友和亲人。在他们死亡之前,许多人将忍受大手术,多年依赖药物以及终末生活的不确定性。寻找治疗方法的动机是巨大的。如果有一种简单的治疗方法可以消除心脏直视手术,甚至可以完全预防心脏病发作怎么办?听起来好得令人难以置信?好吧,有一个陷阱。患者将被注射蛋白质或编码它们的DNA。但是这些“生长因子”与癌细胞泵出的蛋白质相同,可以诱骗人体发芽新的毛细血管来滋养肿瘤。可以理解,癌症研究人员渴望关闭这种血管生成。不过,一些先驱者意识到,能够随意生长血管将是抵抗心血管疾病的强大武器-即使这意味着向患者注入来自肿瘤的DNA片段。

著录项

  • 来源
    《New scientist》 |2002年第2335期|p.36-39|共4页
  • 作者

    Bryant Furlow;

  • 作者单位

    Northern California;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 自然科学总论;
  • 关键词

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