Effect of Endothelin-Converting Enzyme Inhibitors on big Endothelin-1 Induced Contraction in Isolated rat Basilar Artery

M. Zimmermann; C. S. Jung; H. Vatter; A. Raabe; V. Seifert

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Effect of Endothelin-Converting Enzyme Inhibitors on big Endothelin-1 Induced Contraction in Isolated rat Basilar Artery

机译：内皮素转化酶抑制剂对大鼠内皮基底大内皮素-1收缩的影响

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摘要

Introduction: The aim of this study was to investigate whether blocking functional endothelin-converting enzyme (ECE) activity may offer a new approach to inhibit the development of cerebral vasopasm after subarachnoid hemorrhage (SAH) by preventing transformation of big Endothelin-1 (big ET-1) to vasoactive Endothelin-1 (ET-1).

机译：简介：这项研究的目的是研究阻断功能性内皮素转化酶（ECE）的活性是否可能通过防止大内皮素-1（大ET）的转化为抑制蛛网膜下腔出血（SAH）后脑血管生成的发展提供一种新方法。 -1）血管活性内皮素-1（ET-1）。

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《Acta Neurochirurgica》 |2002年第11期|1213-1219|共7页
作者
M. Zimmermann; C. S. Jung; H. Vatter; A. Raabe; V. Seifert;
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作者单位

Department of Neurosurgery Johann Wolfgang Goethe – University Frankfurt/Main Germany;

Department of Neurosurgery Johann Wolfgang Goethe – University Frankfurt/Main Germany;

Department of Neurosurgery Johann Wolfgang Goethe – University Frankfurt/Main Germany;

Department of Neurosurgery Johann Wolfgang Goethe – University Frankfurt/Main Germany;

Department of Neurosurgery Johann Wolfgang Goethe – University Frankfurt/Main Germany;

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Keywords: Cerebral vasospasm; endothelin-converting enzyme inhibitor; endothelin; big Endothelin-1.;

机译：关键词：脑血管痉挛;内皮素转化酶抑制剂内皮素大内皮素-1。;

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1. Attenuation of hemolysate-induced cerebrovascular endothelial cell injury and of production of endothelin-1 and big endothelin-1 by an endothelin-converting enzyme inhibitor. [J] . Chang CZ, Winardi D, Lin CL, Surgical neurology . 2002,第3a4期

机译：内皮素转化酶抑制剂可减轻溶血产物引起的脑血管内皮细胞损伤，并降低内皮素-1和大内皮素-1的产生。
2. Characterization of the contractile and relaxant action of the endothelin-1 precursor, big endothelin-1, in the isolated rat basilar artery. [J] . Schilling L, Vatter H, Mursch K, Peptides: An International Journal . 2000,第1期

机译：内皮素-1前体大内皮素-1在离体大鼠基底动脉中的收缩和松弛作用的特征。
3. Tanshinone IIA inhibits endothelin-1 production in TNF-α-induced brain microvascular endothelial cells through suppression of endothelin-converting enzyme-1 synthesis [J] . Chao TANG, An-hua WU, Hong-li XUE, 中国药理学报：英文版 . 2007,第008期

机译：丹参酮IIA通过抑制内皮素转化酶1的合成来抑制TNF-α诱导的脑微血管内皮细胞中内皮素1的产生
4. RHODIOLA ROSEA RESTORES THE DECLINED BASILAR ARTERY BLOOD FLOW VELOCITY INDUCED BY 39DAY HEAD-DOWN BEDREST [C] . Ming Yuan, Wang Jing, Hongju Liu, International astronautical congress . 2013

机译：RHODIOLA ROSEA恢复了39天平躺式床架引起的下降的基底动脉血流速度
5. Vasoconstrictor Action of Endothelin-1 on Feline and Canine Basilar Arteries利用統計を見る [D] . Mima Tatsuo 1990

机译：内皮素-1对猫和犬基底动脉的血管收缩作用查看用法统计
6. Contraction to big endothelin-1 big endothelin-2 and big endothelin-3 and endothelin-converting enzyme inhibition in human isolated bronchi [O] . E Y S Yap, B Battistini, K O McKay 2000

机译：人分离支气管对大内皮素-1大内皮素2和大内皮素3的收缩以及内皮素转化酶的抑制
7. Contraction to big endothelin-1, big endothelin-2 and big endothelin-3, and endothelin-converting enzyme inhibition in human isolated bronchi [O] . Yap, E Y S, Battistini, B, McKay, K O 2000

机译：人分离支气管对大内皮素-1，大内皮素2和大内皮素3的收缩以及内皮素转化酶的抑制

Effect of Endothelin-Converting Enzyme Inhibitors on big Endothelin-1 Induced Contraction in Isolated rat Basilar Artery

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