Modeling the diffusion of D-2-hydroxyglutarate from IDH1 mutant gliomas in the central nervous system

摘要

Background. Among diffusely infiltrative gliomas in adults, 20%-30% contain a point mutation in isocitrate dehydrogenase 1 (IDH1(mut)), which increases production of D-2-hydroxyglutarate (D2HG). This is so efficient that D2HG often reaches 30 mM within IDH1(mut) gliomas. Yet, while up to 100 mu M D2HG can be detected in the circulating cerebrospinal fluid of IDH1(mut) glioma patients, the exposure of nonneoplastic cells within and surrounding an IDH1(mut) glioma to D2HG is unknown and difficult to measure directly.