Membrane changes during hibernation

摘要

Cellular membranes are susceptible to injury by cold, which causes their lipid components to separate. Here we investigate the structural changes that occur in organelle membranes inside cells of the central nervous system of hypothermic ground squirrels during hibernation. We find that lipids in these membranes sequester into protein-free domains that laterally displace membrane proteins and the underlying cytoplasmic matrix. But when the animal is aroused from hibernation, all these components return to their normal arrangements as the body temperature rises. Understanding this reversible temperature-induced redistribution of membrane lipids should help in the study of the effects of severe cold on non-hibernating species (including humans) and in the cryopreserv-ation of cells and tissues.