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A TRPV family ion channel required for hearing in Drosophila

机译:果蝇听力所需的TRPV家庭离子通道

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摘要

The many types of insect ear share a common sensory element, the chordotonal organ, in which sound-induced antennal or tympanal vibrations are transmitted to ciliated sensory neurons and transduced to receptor potentials. However, the molecular identity of the transducing ion channels in chordotonal neurons, or in any auditory system, is still unknown. Drosophila that are mutant for NOMPC, a transient receptor potential (TRP) super-family ion channel, lack receptor potentials and currents in tactile bristles but retain most of the antennal sound-evoked response, suggesting that a different channel is the primary transducer in chordotonal organs. Here we describe the Drosophila Nanchung (Nan) protein, an ion channel subunit similar to vanilloid-receptor-related (TRPV) channels of the TRP super-family. Nan mediates hypo-osmotically activated calcium influx and cation currents in cultured cells. It is expressed in vivo exclusively in chordotonal neurons and is localized to their sensory cilia. Antennal sound-evoked potentials arc completely absent in mutants lacking Nan, showing that it is an essential component of the chordotonal mechanotransducer.
机译:许多类型的昆虫耳朵共享一个共同的感觉元件,即弦索器官,在该器官中,声诱发的触角或鼓膜振动被传递到纤毛的感觉神经元,并被传递给受体电位。然而,在弦神经元或任何听觉系统中,转导离子通道的分子身份仍然未知。果蝇是NOMPC(瞬时受体电位(TRP)超家族离子通道)的突变体,在触觉刷毛中缺乏受体电位和电流,但保留了大多数触角声诱发的反应,这表明在脊索动物中主要通道是换能器器官。在这里,我们描述了果蝇Nanchung(Nan)蛋白,它是类似于TRP超家族的类香草酸受体相关(TRPV)通道的离子通道亚基。 Nan介导低渗激活的钙离子流和培养细胞中的阳离子流。它在体内仅在弦神经元中表达,并定位于它们的感觉纤毛。在缺乏Nan的突变体中,完全没有触角诱发电位,这表明它是脉络膜机械换能器的重要组成部分。

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