When researchers at Plectix BioSystems in Somerville, Massachusetts, began to use their new Cellucidate software to model the epidermal growth factor receptor pathway, they calculated that there were 10~(33) potential states - including all protein complexes and phosphorylation states - for the system. "This is the kind of complexity that scientists have to grapple with when it comes to cell-signalling networks," says Gordon Webster, vice-president of biology at Plectix.
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