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首页> 外文期刊>Nature >High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
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High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

机译：高含量的全基因组RNAi筛查可确定线粒体上游的帕金调控因子

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摘要

An increasing body of evidence points to mitochondrial dysfunction as a contributor to the molecular pathogenesis of neurodegen-erative diseases such as Parkinson's disease. Recent studies of the Parkinson's disease associated genes PINK1 (ref. 2) and parkin (PARK2, ref. 3) indicate that they may act in a quality control pathway preventing the accumulation of dysfunctional mitochondria. Here we elucidate regulators that have an impact on parkin translocation to damaged mitochondria with genome-wide small interfering RNA (siRNA) screens coupled to high-content microscopy.
机译：越来越多的证据表明，线粒体功能障碍是导致神经退行性疾病（如帕金森氏病）的分子发病机制的原因。帕金森氏病相关基因PINK1（参考文献2）和Parkin（PARK2，参考文献3）的最新研究表明，它们可能在质量控制途径中起作用，可防止线粒体功能障碍。在这里我们用全基因组的小干扰RNA（siRNA）筛查结合高含量显微镜，阐明了调节剂对Parkin转位至受损线粒体的影响。

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  • 来源
    《Nature》 |2013年第7479期|291-295|共5页
  • 作者

    Samuel A. Hasson; Lesley A. Kane; Koji Yamano; Chiu-Hui Huang; Danielle A. Sliter; Eugen Buehler; Chunxin Wang; Sabrina M. Heman-Ackah; Tara Hessa; Rajarshi Guha; Scott E. Martin; Richard J. Youle;

  • 作者单位

    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA,Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, USA;

    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA;

    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA;

    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA;

    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA;

    Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, USA;

    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA;

    NIH Center for Regenerative Medicine, Bethesda, Maryland 20892, USA;

    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA;

    Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, USA;

    Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, USA;

    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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