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Synthesis and characterization of a HAp-based biomarker with controlled drug release for breast cancer

机译：具有控制性药物释放的基于HAp的乳腺癌生物标志物的合成与表征

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摘要

A biocompatible hybrid porous polymer-ceramic material was synthesized to be used as a biomarker in the treatment of breast cancer. This device was equipped with the capacity to release medicaments locally in a controlled manner. The biomaterial was Hydroxyapatite(Hap)-based and had a controlled pore size and pore volume fraction. It was implemented externally using a sharp end and a pair of barbed rings placed opposite each other to prevent relative movement once implanted. The biomarker was impregnated with cis-diamine dichloride platinum (Ⅱ) [Cl_2-Pt-(NH_3)_2]; the rate of release was obtained using inductively coupled plasma atomic emission spectroscopy (ICP-AES), and release occurred over the course of three months. Different release profiles were obtained as a function of the pore volume fraction. The biomaterial was characterized using scanning electron microscopy (SEM) and Raman spectroscopy.
机译：合成了生物相容性杂化多孔聚合物-陶瓷材料，用作乳腺癌的生物标志物。该设备具有以受控方式局部释放药物的能力。该生物材料是基于羟基磷灰石（Hap）的，并且具有受控的孔径和孔体积分数。它是在外部使用一个尖锐的末端和一对彼此相对放置的带刺环实现的，以防止植入后发生相对运动。该生物标记物浸有顺式二胺二氯化铂（Ⅱ）[Cl_2-Pt-（NH_3）_2]；使用电感耦合等离子体原子发射光谱法（ICP-AES）获得释放速率，并且释放历时三个月。根据孔体积分数获得了不同的释放曲线。使用扫描电子显微镜（SEM）和拉曼光谱对生物材料进行表征。

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  • 来源
    《Materials science & engineering》 |2016年第4期|801-808|共8页
  • 作者

    Maykel Gonzalez; Ulises Merino; Susana Vargas; Francisco Quintanilla; Rogelio Rodriguez;

  • 作者单位

    Dept. of Molecular Engineering of Materials, Center of Applied Physics and Advanced Technology, National Autonomous University of Mexico (CFATA-UNAM), Boulevard Juriquilla 3001, Santiago de Queretaro, Queretaro 76230, Mexico;

    Dept. of Molecular Engineering of Materials, Center of Applied Physics and Advanced Technology, National Autonomous University of Mexico (CFATA-UNAM), Boulevard Juriquilla 3001, Santiago de Queretaro, Queretaro 76230, Mexico,University of the Valley of Mexico (UVM), Boulevard Villas del Meson 1000, Juriquilla, Santiago de Queretaro, Queretaro 76320, Mexico;

    Dept. of Molecular Engineering of Materials, Center of Applied Physics and Advanced Technology, National Autonomous University of Mexico (CFATA-UNAM), Boulevard Juriquilla 3001, Santiago de Queretaro, Queretaro 76230, Mexico;

    University of the Valley of Mexico (UVM), Boulevard Villas del Meson 1000, Juriquilla, Santiago de Queretaro, Queretaro 76320, Mexico;

    Dept. of Molecular Engineering of Materials, Center of Applied Physics and Advanced Technology, National Autonomous University of Mexico (CFATA-UNAM), Boulevard Juriquilla 3001, Santiago de Queretaro, Queretaro 76230, Mexico,Dept. of Material Science and Engineering, National Autonomous University of Mexico (UNAM), Center of Applied Physics and Advanced Technology (CFATA), Queretaro, Mexico;

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  • 正文语种 eng
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  • 关键词

    Breast cancer; Biomarkers; Drug controlled release; Implant; Cisplatin;

    机译：乳腺癌;生物标志物;药物控制释放;注入;顺铂;

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