Efficient Synthesis of Aza-Phenanthroindolizidine and Aza-Phenanthroquinolizidine and Anticancer Activities

摘要

Aza-modifications of phenanthroindolizidine and phenanthroquinolizidine alkaloids were firstly designed tonproduce two aza-analogues, 13a-azatylophorine and 14a-aza-7-methoxylcryptopleurine starting from hydrazine monohydratenwith high overall yields, respectively. The synthesis highlighted that some kinds of reactions were ameliorated innmethodology. The newly synthesized target molecules including their salt derivatives were evaluated for anticancer activitiesnagainst the BEL-7402 human liver cancer cell line and MOLT-4 human leukemia cell line. They exhibit anticancernactivities.