Guided Bone Regeneration with Novel Bioabsorbable Membranes

摘要

Guided Bone Regeneration (GBR) is a method for bone tissue regeneration. In this method, membranes are used to cover bone defects and to block the invasion of the surrounding soft tissues. It would provide sufficient time for the osteogenic cells from bone marrow to proliferate and form new bony tissues. In spite of the potential usefulness of this method, no appropriate materials for the GBR membrane have been developed. Here we design the ideal mechanical properties of the GBR membranes and created novel materials, which is the composite of β-tricalcium phosphate and block copolymer of L-lactide, glycolide and ε-caplolactone. In the animal experiments with the use of the trial products, we observed significant enhancement in the bone regeneration and proved the effectiveness of the materials.