Full Control of Regioselectivity in Linear and Angular Polyquinane Construction from Squarate Esters by Incorporation of a Leaving Group into a Single Vinyl Anion Reactant

摘要

We have demonstrated that the squarate ester 1,3,5,7-octatetraene—polyquinane cascade can be regiocontrolled in a manner which can be directed to linear or angular tricyclic products as desired. More elaborate multicyclic systems are expected to be available with equally striking selectivity. The resident multiple functionality in the products holds promise for the useful application of this methodology in a variety of synthetic undertakings.