Highly Diastereoselective Heterogeneously Catalyzed Hydrogenation of Enamines for the Synthesis of Chiral β-Amino Acid Derivatives

摘要

Enantiopure β-amino acids and their derivatives are components of a variety of important natural products and targets for pharmaceutical research. A useful method for preparing compounds of this class in high enantioselectivity involves enantioselective hydrogenation of the corresponding N-acyl protected dehydro-β-amino acid derivative (enamine) using a homogeneous chiral catalyst. However, this method typically requires prior separation of the (Z)- and (E)-enamine isomers from generally poorly selective mixtures to obtain this high enantioselectivity.