Access to Macrocyclic Endocyclic and Exocyclic Allylic Alcohols by Nickel-Catalyzed Reductive Cyclization of Ynals

摘要

Macrocyclic allylic alcohols are a common structural motif in many natural products,and examples of both exocyclic and endocyclic orientations of the alkene unit are frequently observed.Among the known structures,endocyclic allylic alcohols with a 1,2-disubstitution pattern on the alkene are most common.Although many routes to allylic alcohols are known,the reductive coupling of alkynes and aldehydes is perhaps most attractive since the stereogenic center,the alkene stereochemistry,and the carbon-carbon bond that connects the two are simultaneously established.