Pt-Catalyzed Pentannulations from In Situ Generated Metallo-Carbenoids Utilizing Propargylic Esters

摘要

We have developed an efficient method for pentannulation using in situ generated Pt-carbenoid intermediates that arise from readily available propargylic esters. In addition, we have demonstrated that PtCl_2(PPh_3)_2 is a practical precatalyst to effect these transformations. Further studies to probe the mechanism of these transformations, unambiguously identify the catalytically active species, and broaden the scope of these reactions are currently ongoing and will be reported in due course.