Orientational Properties of Stretched Polystyrene Gels in Organic Solvents and the Suppression of Their Residual ~1H NMR Signals

摘要

While residual dipolar couplings (RDCs) are an established method in high-resolution biomolecular NMR,their use for structure determination of small molecules in organic solvents is limited by the alignment media available.Only recently stretched polystyrene (PS) gels were introduced for the measurement of RDCs on small compounds that allowed urgently needed free scalability of the induced anisotropy.Here,the properties of such stretched PS gels in different organic solvents as well as for different magnetic field strengths and temperatures are studied and practical NMR-spectroscopic aspects are discussed.