Retinal Counterion Switch Mechanism in Vision Evaluated by Molecular Simulations

摘要

G protein-coupled receptors (GPCRs) comprise the largest protein family in the human genome,yet rhodopsin is the only member for which there is a high-resolution crystal structure.Understanding GPCR activation is significant due to its role in drug discovery and development.Of ca.500 molecular sites for current drug therapy,cellular membrane receptors are the largest subgroup and represent 45% of all targets.