Lewis Acid-Catalyzed Enantioselective Hydroxylation Reactions of Oxindoles and beta-Keto Esters Using DBFOX Ligand

摘要

3-Hydroxy-2-oxindoles are key structural functionalities throughout natural products and drug candidates.Chiral 3-aryl-3-hydroxy-2-oxindoles are particularly promising molecules in the field of medicinal chemistry represented by SM-130686.Probably the most direct approach to enantioselective synthesis of 3-aryl-3-hydroxy-2-oxindoles is through both asymmetric nucleophilic arylation of isatins and enantioselective electrophilic hydroxylation of 3-aryl-2-oxindoles.