Mixed La-Li Heterobimetallic Complexes for Tertiary Nitroaldol Resolution

摘要

Catalytic asymmetric nitroaldol(Henry)reactions'of ketones lead to synthetically versatile chiral tertiary nitroaldols.Enantiose-lective nitroaldol reactions of alpha-keto esters have been achieved using chiral Cu~(2a-d)and Mg complexes~(2e)and cinchona alkaloids;however,there are no reports on the asymmetric synthesis of tertiary nitroaldols derived from simple ketones.Even for a racemic version,only a few methodologies with limited substrate scope are available.