A Selective Activity-Based Probe for the Papain Family Cysteine Protease Dipeptidyl Peptidase I/Cathepsin C

摘要

Dipeptidyl peptidase I (DPPI),also known as cathepsin C,is a lysosomal cysteine hydrolase expressed in most mammalian tissues.In myeloid cells and cytotoxic lymphocytes,it is found in secretory granules where it is solely responsible for NH_2-prodipeptide removal and catalytic activation of several leukocyte-derived serine proteases,including mast cell chymases (mMCP4 and mMCP5),neutrophil elastase (NE),cathepsin G,and cytotoxic lymphocyte-derived granzymes A and B.