Stereoselective Alkylation of α , β-Unsaturated Imines via C-H Bond Activation

摘要

The stereoselective alkylation of α , β-unsaturated imines via the directed activation of a C- H bond by a rhodium catalyst has been achieved. Use of the electron-donating (dicyclo-hexylphosphinyl)ferrocene ligand provides a catalyst that is active at mild temperatures, producing the Z isomer exclusively prior to hydrolysis and allowing for good functional group compatibility, including the use of alkynes to form alkenylated products. Further progress on the synthesis of β, β-trisubstituted and tetrasubstituted enals is currently underway. This method promises to provide a straightforward route to these valuable synthetic intermediates.