Cinchona Alkaloid-Catalyzed Enantioselective Monofluoromethylation Reaction Based on Fluorobis(phenylsulfonyl)methane Chemistry Combined with a Mannich-type Reaction

摘要

We have described the first catalytic enantiose-lective fluorobisphenylsulfonylmethylation of in situ generated imines from α-amido sulfones under the combination of Mannich-type conditions with FBSM chemistry. The α-fluorobisphenylsul-fonylmethylated amines were converted to α-monofluoromethyl amines by reductive desulfonylation. Application to the synthesis of biologically important molecules is currently under investigation via the FBSM/Mannich strategy.