Asymmetric Conjugate Alkenylation of Enones Catalyzed by Chiral Diols

摘要

We have developed the first catalytic asymmetric conjugate alkenylation methodology that does not rely on a heavy metal. The alkenylboronates used are readily accessible as are the binaphthol catalysts. Enantioselectivities are uniformly high for a wide range of enones and alkenyl groups. Efforts are underway to expand the scope of these reactions.