Intra- And Intermembrane Pairwise Molecular Recognition Between Syntheticrnhydrogen-bonding Phospholipids

摘要

Multivalency and preorganization are fundamental aspects of molecular recognition at the lipid membrane-water interface and can render weak monomeric binding interactions selective and robust; this concept is important throughout biology, biotechnology, and materials science. We previously described how small molecule recognition between membranes is sufficient to selectively merge vesicular membranes; recent reports have indicated similar membrane chemistry directed by nucleic acid recognition. These systems all utilize hydrogen bond (H-bond) donor-acceptor pattern recognition between complex natural products or large biomolecules to guide membrane chemistry, which prompted our examination of yet simpler hydrogen bonding systems to study multivalent surface recognition in water. Intramembrane hydrogen bonding between native lipids has been well-documented and is thought to contribute to lipid bioactivity and membrane function.