Real Time Imaging Of Supramolecular Assembly Formation Via Programmedrnnucleolipid Recognition

摘要

The synthesis of supramolecular systems using weak noncovalent chemical bonds to assemble molecules is an important and increasingly successful strategy. These supramolecular assemblies represent diverse structures and span length scales from a few nanometers to millimeters, with examples reported such as DNA scaffolds, nucleolipoplexes, peptide nanofibers, reversible polymers, dendritic assemblies, and nanotubes. Elucidation and control of the factors that govern the recognition events at the molecular level represent a significant advantage to construct functional or intricate systems. To this end, our interest is in using increasingly complex molecules capable of forming programmable supramolecular systems. Nucleolipids possessing both nucleic acid recognition and lipophilic chains components are emerging as building blocks for constructing such assemblies because these amphiphiles possess a diversity of functional groups capable of cooperative noncovalent interactions combined with specific base-base recognition.