Manganese-based Nanoscale Metal-organic Frameworks For Magneticrnresonance Imaging

摘要

Magnetic resonance imaging (MRI) is a powerful nomnvasive diagnostic tool that provides high spatial resolution images and does not involve radioactivity. Intrinsically low sensitivity of MRI however necessitates the use of contrast agents that are often administered in high doses. Paramagnetic and superparamagnetic nanomaterials have recently emerged as promising MR contrast agents owing to their ability to carry large payloads of magnetic centers. They can work at very low concentrations and be made target-specific by conjugation with affinity molecules.rnWe recently demonstrated the synthesis of Gd-based nanoscale metal-organic frameworks (NMOFs) with extraordinarily high MR relaxivities on a per particle basis. The toxicity of leached Gd~(3+) ions however precludes clinical applications of these NMOFs.