Monitoring of Biological One-Electron Reduction by ~(19)F NMR Using Hypoxia Selective Activation of an ~(19)F-Labeled Indolequinone Derivative

摘要

Intracellular reductases have been closely linked with activation of certain drugs and probes in the tumor-specific microenviron-ments.Among various enzymes, reductases that catalyze one-electron reduction are involved in the selective activation of functional compounds or materials under hypoxia,a well-known pathophysiological characteristic of solid tumors.Such an enzymatic one-electron reduction has been recognized to be a useful reaction applicable to the design of a tumor hypoxia targeting and imaging strategy. Thus, further quantitative insights into the features of this reaction are important.