An Efficient Process for Pd-Catalyzed C-N Cross-Coupling Reactions of Aryl Iodides: Insight Into Controlling Factors

摘要

In Pd-catalyzed C-C cross-coupling reactions aryl iodides have generally been better substrates than the corresponding aryl bromides or chlorides. However, this has not been the case for Pd-catalyzed C-N bond-forming processes, in which aryl iodides have traditionally been the least successful substrates of these three aryl halides. Recent advances in this field have allowed for reactions of aryl chlorides to reach the same efficiencies as aryl bromides, but relatively little progress has been made in increasing the proficiency of Pd-catalyzed C-N cross-coupling processes using aryl iodides.