Surpassing the Use of Copper in the Click Functionalization of Polymeric Nanostructures: A Strain-Promoted Approach

摘要

With the aim of developing stable polymeric carriers for drug delivery, we and others have recently turned our attention to chitosan-g-poly(ethylene glycol). Chitosan (CS) is a linear polysac-charide comprising glucosamine and N-acetylglucosamine that is characterized by high biocompatibility and biodegradability. The presence of poly(ethylene glycol) (PEG) in the resulting CS-g-PEG nanostructures is aimed at modifying their biodistribution and enhancing their biocompatibility, stability, and circulation times in the bloodstream.