Photoregulated Release of Caged Anticancer Drugs from Gold Nanoparticles

摘要

A key attribute of drug delivery systems (DDSs) is their ability to regulate drug release, minimizing side effects and improving therapeutic efficacy of conventional Pharmaceuticals. Two approaches can be used to regulate the release of the therapeutic payload from the carrier: endogenous and exogenous activation. Endogenous activation strategies exploit specific physiochemical characteristics of the pathological microenvironment, providing biologically controlled release. Exogenous activation provides a complementary approach, employing orthogonal external stimuli to effect drug release.