Phosphine-Catalyzed Formation of Carbon-Sulfur Bonds: Catalytic Asymmetric Synthesis of γ-Thioesters

摘要

Chiral sulfur-containing compounds have important applications in many areas of chemistry and biology, serving, for example, as antibiotics, as ligands for metal-based catalysts, as catalysts themselves, and as chiral auxiliaries. With respect to the catalytic enantioselective synthesis of sulfur-containing molecules, the conjugate addition of thiols to the β position of α, β-unsaturated carbonyl compounds has been the focus of intense interest.