Catalytic Dicyanative [4+2] Cycloaddition Triggered by Cyanopalladation of Conjugated Enynes under Aerobic Conditions

摘要

Ever since a cyano group was recognized as a useful functionality, its introduction, in particular to carbon-carbon triple bonds by Ni(0)- or Pd(0) complexes with X-CN (X = H,~1 Si,~2 Ge,~3 Sn,~4 S,~5 C,~5 B~7), has been a major topic in synthetic organic chemistry. Recently, we developed a catalytic 1,2-dicyanation of alkynes by Pd(II) under aerobic conditions and revealed that this reaction involves direct nucleophilic cyanation to C-C triple bonds (anti-and syn-cyanopalladation).