Enantioselective Synthesis of Highly Substituted Furans by a Copper(Ⅱ)-Catalyzed Cycloisomerization-lndole Addition Reaction

摘要

A catalytic enantioselective reaction based on a copper(Ⅱ) catalyst strictly containing chiral anionic ligands is described. In the present work, copper(Ⅱ)-phosphate catalyst promotes the intramolecular heterocyclization of 2-(l-alkynyl)-2-alkene-l-ones and facilitates high levels of enantioselectivity in the subsequent nucleophile attack. Mechanistic studies suggest that formation of a copper(Ⅱ) -indole species is important for catalysis.