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Specific Detection of D-Glucose by a Tetraphenylethene-Based Fluorescent Sensor

机译:基于四苯乙烯的荧光传感器对D-葡萄糖的特异性检测

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摘要

A conceptually new "light-up" biosensor with a high specificity for D-glucose (Glu) in aqueous media has been developed. The emission from a tetraphenylethene (TPE)-cored diboronic acid (1) was greatly boosted when the fluorogen was oligomerized with Glu because of restriction of the intramolecular rotations of the aryl rotors of TPE by formation of the oligomer. Little change in the light emission was observed when 1 was mixed with D-fructose, D-galactose, or D-mannose, as these saccharides are unable to oligomerize with the fluorogen.
机译:已经开发出对水介质中的D-葡萄糖(Glu)具有高度特异性的概念上新颖的“发光”生物传感器。当氟与Glu齐聚时,由于通过形成低聚物而限制了TPE芳基转子的分子内旋转,因此大大提高了以四苯乙烯(TPE)为核心的二硼酸(1)的发射。当将1与D-果糖,D-半乳糖或D-甘露糖混合时,几乎看不到发光的变化,因为这些糖不能与氟齐聚。

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  • 来源
    《Journal of the American Chemical Society》 |2011年第4期|p.660-663|共4页
  • 作者单位

    Institute of Biomedical Macromolecules, Department of Polymer Science and Engineering, MoE Key Laboratory of Macromolecule Synthesis and Functionalization, Zhejiang University, Hangzhou 310027, China;

    Department of Chemistry, Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China;

    Institute of Biomedical Macromolecules, Department of Polymer Science and Engineering, MoE Key Laboratory of Macromolecule Synthesis and Functionalization, Zhejiang University, Hangzhou 310027, China;

    Institute of Biomedical Macromolecules, Department of Polymer Science and Engineering, MoE Key Laboratory of Macromolecule Synthesis and Functionalization, Zhejiang University, Hangzhou 310027, China;

    Department of Chemistry, Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China;

    Institute of Biomedical Macromolecules, Department of Polymer Science and Engineering, MoE Key Laboratory of Macromolecule Synthesis and Functionalization, Zhejiang University, Hangzhou 310027, China;

    Institute of Biomedical Macromolecules, Department of Polymer Science and Engineering, MoE Key Laboratory of Macromolecule Synthesis and Functionalization, Zhejiang University, Hangzhou 310027, China,Department of Chemistry, Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China;

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  • 正文语种 eng
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